They resided in Des Moines and were the parents of two children, Edwin T. "Ed" Meredith II, and Mildred M. Bohen.

Meredith ran the Farmer's Tribune until 1902, when he began publishing his own magazine, Successful Farming, which reached 100,000 subscribers by 1908.

Despite his unsuccessful campaigns, Meredith maintained a high profile among rural voters and farmers because of his magazine.

As a result, Woodrow Wilson appointed him to the Treasury Department's Advisory Committee on Excess Profits, and he served on the board of directors of the Federal Reserve Bank of Chicago from 1918 until 1920.

When the convention deadlocked, Meredith allowed his name to be put forward as Iowa's favorite son before the nomination went to John W. Davis on the 103rd ballot.