Edwin W. and Charlotte Clarke House is a historic home located at Oswego in Oswego County, New York.

It is a 2+1⁄2-story brick Italianate style residence built in 1857.

Edwin W. and Charlotte Clarke were prominent abolitionists and it is believed that the house was a way station on the Underground Railroad.

[2] It was listed on the National Register of Historic Places in 2002.

This article about a historic property or district in Oswego County, New York, that is listed on the National Register of Historic Places, is a stub.