Edwin Warren Moïse was born on January 2, 1810, in Charleston, South Carolina.

[2] He grew up in Charleston, and attended Congregation Kahal Kadosh Beth Elohim with his family.

[2] Moïse worked as a physician in Woodville, Mississippi, an affluent town thanks to the cotton industry.

[2][5] During the American Civil War of 1861–1865, Moïse served as the District Court Judge for Louisiana.

They had four sons and one daughter: Moïse died on June 29, 1868, in Jefferson, Louisiana.