Seeking to raise money for her NGO, Bindu visits the office of a rich and powerful industrialist named Sudeep, who also finds her attractive and starts lusting for her.

Sudeep gets scared, and arranges to kill Nani at his home, but the fly escapes after causing a short circuit and a fire, which locks up the room.

Sudeep kills Adithya to collect a ₹700 crore (US$130 million)[d] insurance policy, as well as to prevent his investors from taking action against his company.

Knowing that he is dying, in a last-ditch attempt to destroy Sudeep, Nani coats himself with gunpowder and jumps through the flame of a burning match and into a cannon, which was loaded with a steel ball.

[16] Prasad later developed the idea as a script for an English-language film set in 1830s America, in which an African-American boy dies in an attempt to free his family from slavery and is reincarnated as a fly.

[24] Rajamouli chose Sudeepa to play the fly's human adversary after being impressed with the actor's performance in Rann (2010),[19] and cast rapper Noel Sean as Nani's friend in the film.

[25] Sudeepa drew inspiration for his role as the villain from the 1983 Kannada film Bhakta Prahlada;[26][27] he was portraying a character he considered to be a "bad guy" with "grey shades" rather than an antagonist.

[29][30] James Fowlds was initially chosen as the film's director of photography,[31] but was replaced by K. K. Senthil Kumar due to creative differences and scheduling conflicts.

[49] Ajay Devgan and his wife Kajol, acting as parents telling the film's story to their child at bedtime, provided voiceovers during the opening credits of Makkhi.

[50] The visuals accompanying the closing credits were altered to show the fly mimicking the antics of Devgan, Salman Khan, and Akshay Kumar.

[51] R. C. Kamalakannan and Pete Draper of Makuta VFX oversaw Eega's visual effects,[52][53] and Rahul Venugopal was the film's set supervisor and matte painter.

[62] Mohan told Malathi Rangarajan of The Hindu that although the film's script may resemble those of Stuart Little (1999) and Shrek (2001), the use of the plight of someone tormented by a housefly was an original idea.

[63] Malini Mannath of The New Indian Express found the scene where the fly foils Sudeepa's attempt to get close to Bindu reminiscent of one in the film Ghost (1990).

[70][h] Keeravani said because the film's theme of revenge and the protagonist (a housefly) are universal concepts, his "only challenge" was ensuring the music did not have a "distinct ethnic or regional flavour" and "appeal".

[71] Rajamouli approached Madhan Karky to write the lyrics for Naan Ee's soundtrack after the release of Enthiran (2010), explaining the importance of each song in the film's narrative.

[72] Eega's soundtrack was released on 4 April 2012 at a promotional event at Shanti Sarovar, Brahma Kumaris' academy in Gachibowli, a suburb of Hyderabad.

[76] Writing for The Hindu, Sangeetha Devi Dundoo called the soundtrack "melodious ... sharply contrasted by the background score, which seamlessly moves from sober to playful to pulsating".

[91] Rajamouli added that a database of IP addresses of non-resident Indians who frequently download content was shared with immigration authorities which could affect their potential US residence permit applications.

[92] Naan Ee's satellite television rights were sold to Sun TV for ₹3.35 crore—a record price for a Telugu director's film, exceeding Rajamouli's initial expectations.

Hurtado called the audio a "thing of beauty, giving good separation and a booming low end that puts you in the middle of the Eega action in a way that even my theatrical experience couldn't do".

[82][d] Indo-Asian News Service stated that Eega was the highest-grossing Telugu film of 2012,[106] but Bangalore Mirror said it was the second-highest (after Gabbar Singh) in box-office revenue.

[110] Baradwaj Rangan, writing for The Hindu, said without a human protagonist, only a villain and a heroine, the audience is "led through a story that's funny, sentimental, action-packed, romantic—there's even a bit of the occult thrown in".

[67] Karishma Upadhyay of The Telegraph called the film "a winner from the first frame to the last" and praised Rajamouli's screenplay, writing that it made "the absurd seem real, willing you to accept anything that he throws at you".

[114] Radhika Rajamani of Rediff.com awarded Eega four stars out of five; she praised its visual effects, performances and cinematography and said Sudeepa "is such a delight to watch on screen".

[78][14] Rajeev Masand of News18 gave the film four stars out of five and praised its concept, and said Sudeepa played his role with a "true comic book flair" and a "cartoonish tinge".

[118] Shabana Ansari rated Eega three stars out of five in a Daily News and Analysis review and called the animated fly a "new-age Indian hero" with "lofty ideas".

[68] Reviewing Makkhi for Dainik Bhaskar, Mayank Shekhar said the film's premise is stretched beyond its potential and that as a result, it "just goes on and on and on" in its "original, tacky, raw form".

[127][128] Ravinder Reddy won the Best Art Direction Award at the 2013 Fantaspoa International Fantastic Film Festival in Brazil for his work in Eega.

[147] Eega was parodied twice in Bhimaneni Srinivasa Rao's comedy film Sudigadu (2012); when a young girl asks her father to tell her a bedtime story in the opening credits,[148] and in a scene in which the protagonist threatens to kill a female crime boss with weapons designed by Rajamouli, including the fly's needle.

[155] In August 2015, Pooja Darade of The Times of India included Eega in her list of "Telugu movies one must watch before dying"; she said it "has set a high standard of how creativity can be used effectively".