Einhorn–Brunner reaction

[1] In 1914 chemist Karl Brunner published a paper expanding on Einhorn's research of the reaction pictured below, thus resulting in the naming as the Einhorn-Brunner.

In their research on the synthesis of 1,2,4-triazoles, Potts determined that the strongest acidic group attached to the side of the imide will be favored for the 3 position on the triazole ring.

Intramolecular attack of the electrophilic carbonyl carbon by the nitrogen, resulting in a 5-membered ring closure of the positively charged 6.

[citation needed] The Einhorn–Brunner reaction maintains scientific importance and relevance in the production of 1,2,4-triazoles, which can be further substituted for their medicinal value.

Research done by Pattan et al., specifically on 1,2,4-triazoles, found antibacterial, antifungal, antitubercular, and anti-inflammatory activity of variously substituted compounds.