The El Camino Real de los Tejas National Historic Trail is a national historic trail covering the U.S. section of El Camino Real de Los Tejas, a thoroughfare from the 18th-century Spanish colonial era in Spanish Texas, instrumental in the settlement, development, and history of Texas.

The growth of towns such as Austin, Galveston, and Houston not on the original route, along with the building of railroads, changed the direction of travel and trade and the use of El Camino Real de los Tejas diminished.

For centuries, the Native Americans had used the trail routes for trading between the Great Plains and Chihuahuan Desert regions and essentially created the road.

It was one of several named El Camino Real, or "Royal Road", that connected the Spanish possessions in North America with Mexico City.

In October 2004, President George W. Bush signed into law El Camino Real de los Tejas National Historic Trail.