Currently the show has nine main collaborators: Sandra Sabatés, Thais Villas, Dani Mateo, Joaquín Reyes, Guillermo Fesser, Álvaro Carmona, Iván Lagarto, Manuel Burque, Andrea Ropero and Sara Escudero.

The show's theme tune until 2022, called "Give me a break", was composed especially for the program by Juan Carlos Cuello and produced by Sound Garden Producciones.

In its first season (spring of 2006), as a weekly recorded program; had as collaborators Javier Cansado, Juan Luis Galiardo and Jimmy Barnatán.

In September 2008, Yolanda Ramos and Cristina Peña left the program and two new collaborators joined it: África Luca de Tena and the Argentinian Lara Ruiz.

[14] In September 2009; on the verge of the beginning of a new season, it was confirmed the abandonment of Lara Ruiz and África Luca de Tena and the incorporation of Tania Llasera as new reporter, substituting those aforementioned.

In March 2010, Fridays’ edition was cancelled and, instead, la Sexta, started to emit films, which caused the leaving of Juanra Bonet.

[23] On 9 November 2016, Guillermo Fesser joins the show, carrying out his usual collaborations in the program from the United States, coinciding with Donald Trump's victory in the Presidential elections in this country.

[24][25] Its historical record of viewers corresponds to the emission of the Monday 25 May 2015, with 3.291.000 spectators, (17.4% of share), the day after the Local elections and with the visit of the candidate to Madrid's City Hall Manuela Carmena.

Since its first program in 2011, its structure changed and starts a section called "La actualidad en 1 minuto" in which the news and events that happen all around the world are described in barely a minute.

Since the season 2013–2014, this section has been substituted by an overview of the main news without a stipulated timing, in which the different collaborators participate alternatively, with the exception of Thais Villas (interviews), who appears at the end.