Unlike the previous season, Lisa Owen, Alberto Guerra, Alejandro López, Fernando Noriega and Roberto Escobar were removed from the main cast and Rafael Amaya only appears as a special guest stars.

What he does not know is that Baltazar Ojeda (Eduardo Santamarina), a CIA Agent, has the plan to eliminate Amado before, since he is the only one who can prove that within the organization in which both worked together, there is a scheme of corruption and murky management that endangers its existence within it and its freedom.

In the midst of this tension and in parallel, under the supervision of Doña Alba (Lisa Owen) and a specialized doctor, they try a risky procedure to revive Aurelio (Rafael Amaya).

[81] Surpassing El Dragón: Return of a Warrior of Univision and becoming the most watched program during the year in Telemundo,[81] only above La Reina del Sur,[81] despite having had a successful premiere; the series failed to reach two million viewers as in past seasons.

[89] On 16 July 2019, Jesús Moré who played Omar Terán confirmed his departure from the series and said "I think it's a good decision, I think the character gave what he had to give in the sixth season.

[93] On 14 August 2019, People en Español magazine confirmed that Isabella Castillo, Carmen Aub, Karla Carrillo, Iván Arana, Fernando Noriega, Alejandro López, Álex Walerstein, Ninel Conde, Dayana Garroz, and Alberto Guerra would be back in the season.

[94] Subsequently, on 17 September 2019, the magazine confirmed the return of Eduardo Santamarina, Robinson Díaz, and Fernando Noriega to the season,[1] as well as the inclusion of new characters such as Manuel Landeta, and Julián Román among others.