El Señor de los Cielos (in English: Lord of the Skies) is an American crime drama television series created by Luis Zelkowicz, based on an original idea by Mariano Calasso, and Andrés López.

Aurelio ends up being cornered by the authorities after being found as he decides to undergo a face operation in which he supposedly dies, thus causing his empire of power to fall.

In season two, believed to be dead, Aurelio returns to enact his revenge on police officer Leonor Ballesteros (Carmen Villalobos), who through her fault ends up operating his face in a failed attempt to escape from the authorities.

After all the problems with the government and the DEA, Aurelio learns that he suffers from kidney failure and decides to remember his past in order to find his lost son.

Later, Aurelio (Rafael Amaya), will also face a serious illness, which puts at stake his power and prestige since this man fails to get a donor, so they can make his transplant, necessary to continue living.

But it is time for retribution, the hatred that he sowed since he sold his soul to the drug trafficking demon is now knocking on his door with the face and blood of the many innocent people he destroyed.

What he does not know is that Baltazar Ojeda (Eduardo Santamarina), a CIA agent, has the plan to eliminate Amado before, since he is the only one who can prove that within the organization in which both worked together, there is a scheme of corruption and murky management that endangers its existence within it and its freedom.

He has already been transferred to a jail on the outskirts of the State of Mexico and is about to be taken to the airport, under strict security measures when the Casillas cartel tries to rescue him and Baltazar Ojeda himself tries to kill him.

In the midst of this tension and in parallel, under the supervision of Doña Alba (Lisa Owen) and a specialized doctor, they try a risky procedure to revive Aurelio (Rafael Amaya).

[26] In the fifth season of El Señor de los Cielos, there is a crossover with Dueños del Paraíso when the main villain of Dueños del Paraiso, Leandro Quezada (Miguel Varoni), the head of Santa Norma Cartel (or Cartel de Santa Norma) goes to war against Aurelio Casillas for the control of drug trafficking and becomes the fiercest opponent that Aurelio Casillas has ever faced.

[28] Another crossover between El Señor de los Cielos and La Doña occurs in the second season when the characters Eunice Lara "La Felina" (Maricela González), and Amado Casillas "El Águila Azul" (Matías Novoa), two of the main characters of El Señor de los Cielos become recurring characters in La Doña[29] During the broadcast of the second season, Telemundo published a comic based on the second season of the series, portraying part of the plot of the series.

[35] In the fifth season the opening theme titled "El quinto corrido", this time performed by Don Chayo, member of the band Cardenales de Nuevo León.

In the eighth season the opening theme is titled "Hierba mala nunca muere", performed by Los Tucanes de Tijuana.