Four singles were released from the album: "Amar sin ser amada", "Un alma sentenciada", "Seducción" and "Olvídame", all of them became moderate hits on the charts.

Two of the three new songs were released as singles: "Cantando por un sueño" and "No, no, no", the latter is a duet with American bachata singer Anthony "Romeo" Santos.

El Sexto Sentido was the most expensive album during its release in Latin American and Thalía set a record for the largest number of interviews granted to an electronic medium, Televisa.

On the other hand, El Sexto Sentido Re+Loaded (a reissue of this album) included the bachata-ballad styled song "No, no, no" featuring American singer Anthony "Romeo" Santos.

Lyrically, it talks about the loss of a loved one as in "Olvídame", optimism as in "No Me Voy a Quebrar", fun as in "Seducción" and even to an extremely sensual point in "Sabe Bien".

The lead single, "Amar sin ser amada", is a song that instantly impressed the female audience, thus peaking at the first positions on the charts of Latin America and some European countries.

On July 28, 2005, only two weeks after the album's release, El Sexto Sentido was certified gold in Mexico by AMPROFON for sales/shipments of 50,000 copies within the country.

[6] This album was a financial success internationally according to Leila Cobo from Billboard and became the first Spanish-language release in the United States to have a preorder campaign through iTunes.

[8] Johnny Loftus from AllMusic gave the album a mixed review and wrote that it's "a straightforward Latin pop album, with the requisite balladry (the rousing "Olvídame" really shows off her voice), bouncy hybrid pop (the bandoneon-flavored opener, "Amar Sin Ser Amada"), and exuberant anthems you can imagine the entire dancefloor singing along with ("Seducción," "No Me Voy a Quebrar") but noted that "while it will likely appeal to her die-hard fans, Thalía's El Sexto Sentido is neither up to her superstar standard nor a domestic breakthrough.

Two of the three new songs were released as singles: "Cantando por un sueño"[12] and "No, no, no", the latter is a duet with American bachata singer Anthony "Romeo" Santos.