Casuarina is an entirely urban electorate, covering only 12 km2 and taking in the suburbs of Brinkin, Nakara, Tiwi and part of Alawa, as well as the Charles Darwin University.

For the first three decades of its existence, Casuarina, like most seats in the Darwin area, was a stronghold for the Country Liberal Party.

Clare Martin did nearly manage to take the seat for the Labor Party upon the retirement of long-serving CLP member Nick Dondas in 1994, but lost out to the CLP's Peter Adamson, who held the seat for the next seven years.

It was still widely presumed to be a safe Liberal seat in 2001, when it unexpectedly fell to Labor challenger Kon Vatskalis as part of Labor's sweep of the northern suburbs that year en route to winning government for the first time.

Moss picked up enough of a swing in 2016 to make Casuarina much more secure for Labor, and consolidated her hold on the seat in 2020.