[1][2][3][4] Public Image Ltd. (PiL) made their Irish debut at the festival while The Frames appeared in their twentieth anniversary year.
[8] Among the first acts announced were Roxy Music, Public Image Ltd., Massive Attack, Leftfield, Mumford & Sons, Jón Þór Birgisson, Gil Scott-Heron, LCD Soundsystem, Booka Shade, Crystal Castles, The Big Pink, 808 State, Modest Mouse, Fever Ray, Beach House and Seasick Steve.
[2][3][7][9] Among the first Irish acts announced were The Frames, Paul Brady, Villagers, Imelda May, Choice Music Prize winner Adrian Crowley, rap duo Messiah J and the Expert, Afro-Celt Sound System and The Rubberbandits—a pair of Limerick rappers who perform with plastic bags over their heads and who noted for their ditty on Willie O'Dea composed following his resignation as Minister for Defence.
[2][3] Fringe areas such as the Body and Soul Arena, the Arts Trail, Mindfield Spoken Word, Lucent Dossier Experience, Greencrafts and Global Green and Discovery were all confirmed to be included in 2010 alongside a circus and comedy events.
[19] On 21 July, the following were announced: Robyn, Two Door Cinema Club, Laura Marling, The Antlers, The Tallest Man on Earth, Cymbals Eat Guitars, Chew Lips, Fang Island, The Riptide Movement, Donal Dineen and Brian Deady.
[20] On 4 August, more acts were announced: Janelle Monáe, Duke Special, Dennis Alacapone & The Dubcats, Mountain Man, Neon Indian, Freelance Whales, Hurts, Delta Maid, O Emperor, Joe Echo and Vengeance & The Panther Queen.