Electrical impedance tomography

[2][4][7] Further EIT applications proposed include detection/location of cancer in skin, breast, or cervix, localization of epileptic foci,[8] imaging of brain activity.

In analogy to EIT, surface electrodes are being placed on the earth, within bore holes, or within a vessel or pipe in order to locate resistivity anomalies or monitor mixtures of conductive fluids.

The procedure will then be repeated for numerous "stimulation patterns", e.g. successive pairs of adjacent electrodes until an entire circle has been completed and image reconstruction can be carried out and displayed by a digital workstation that incorporates complex mathematical algorithms and a priori data.

Another approach is to construct a finite element model of the body and adjust the conductivities (for example using a variant of Levenburg–Marquart method) to fit the measured data.

Absolute EIT approaches are targeted at digital reconstruction of static images, i.e. two-dimensional representations of the anatomy within the body part of interest.

It is also important to bear in mind that the body part of interest is rarely precisely rotund and that inter-individual anatomy varies, e.g. thorax shape, affecting individual electrode spacing.

[7] However, incorporating a priori data sets or meshes in difference EIT is still useful in order to project images onto the most likely organ morphology, which depends on weight, height, gender, and other individual factors.

[28] While initial studies assessing aspects of absolute EIT have been published, this area of research has not yet reached the level of maturity which would make it suitable for clinical use.

These attributes make regional lung function monitoring particularly useful whenever there is a need to improve oxygenation or CO2 elimination and when therapy changes are intended to achieve a more homogenous gas distribution in mechanically ventilated patients.

[43] The high temporal resolution of EIT allows regional assessment of common dynamic parameters used in pulmonary function testing (e.g. forced expiratory volume in 1 second).

The models are currently being installed in intensive care units and are already used as aides in decision-making processes related to the treatment of patients with acute respiratory distress syndrome (ARDS).

Development of alternative imaging techniques for this indication would be desirable due to the shortcomings of the existing methods: ionizing radiation in mammography and the risk of inducing nephrogenic systemic fibrosis (NSF) in patients with decreased renal function by administering the contrast agent used in breast MRI, Gadolinium.

An early commercial development of non-tomographic electrical impedance imaging was the T-Scan device [53] which was reported to improve sensitivity and specificity when used as an adjunct to screening mammography.

A report to the United States Food and Drug Administration (FDA) describes a study involving 504 subjects where the sensitivity of mammography was 82%, 62% for the T-Scan alone, and 88% for the two combined.

According to a study published by Brown in 2000, MF-EIT is able to predict [Cervical intraepithelial neoplasia] (CIN) grades 2 and 3 according to Pap smear with a sensitivity and specificity of 92% each.

The device received EC certification from its Notified Body in 2013 and is currently being introduced into a number of clinics in the UK and healthcare systems across the globe.

[8] This makes EIT also interesting for monitoring normal brain function and neuronal activity in intensive care units or the preoperative setting for localization of epileptic foci by telemetric recordings.

[58] A study reported in June 2011 that Functional Electrical Impedance Tomography by Evoke Response (fEITER) has been used to image changes in brain activity after injection of an anaesthetic.

[4][59] Background of this approach is that pulsatile tissue impedance changes according to differences in the filling of blood vessels between systole and diastole, particularly when injecting saline as contrasting agent.

Recent advances in EIT technology as well as the lower number of electrodes required for recording global instead of regional parameters in healthy individuals can be used for non-invasive determination of e.g. VO2 or arterial blood pressure in sports medicine or home care.

Timpel Medical has now released their second generation ENLIGHT 2100 and is the only FDA cleared electrical impedance tomography device commercially available in the United States.

These systems typically comply with medical safety legislation and have been primarily employed by clinical research groups in hospitals, most of them in critical care.

The first EIT device for lung function monitoring designed for everyday clinical use in the critical care environment has been made available by Dräger Medical in 2011 – the PulmoVista® 500 (16-electrode system).

New strategies in artificial ventilation began to be developed through a research project, led by Marcelo Amato MD, PhD, University of São Paulo pulmonologist, between 2002 and 2008.

Because of the tremendous interest in EIT and the value the technology brings to the bedside, researchers around the world have contributed to the body of evidence with more than 250 peer reviewed publications in press by 2022.

Timpel is passionate and motivated: to make EIT a valuable adjunctive tool for lung protective strategies contributing to the next generation methodology of treating critically ill patients at the bedside.

ENLIGHT gives the Clinicians visibility of the ventilation disease profile in real time, at the bedside without the added risk of transportation.

Multifrequency-EIT (MF-EIT) or electrical impedance spectroscopy (EIS) systems are typically designed to detect or locate abnormal tissue, e.g. precancerous lesions or cancer.

Impedance Medical Technologies manufacture systems based on designs by the Research Institute of Radioengineering and Electronics of the Russian Academy of Science in Moscow, that are aimed especially at breast cancer detection.

Zilico Limited distributes an electrical impedance spectroscope named ZedScan I as a medical device supposed to aid cervical intraepithelial neoplasia location/diagnosis.

In this prototype, the electrodes are attached around a grapefruit which represents a child's head. Liquid is injected into the grapefruit to mimic brain haemorrhage.
Adhesive electrodes on chest of a 10-day-old baby [ 40 ]
EIT reconstruction (left) and impedance change over six breaths, from. [ 40 ] Data available on [ 41 ]