[1][2] Aprile studied physics at the University of Naples and completed her masters thesis at CERN under the supervision of Professor Carlo Rubbia.

[4] She began working on liquid argon detectors as a graduate student at CERN, continuing her research as a postdoctoral fellow at Harvard.

[5] This work led to the realization of the first liquid xenon time projection chamber (LXeTPC) as a Compton telescope for MeV gamma rays.

LXeGRIT used a liquid xenon time projection chamber as a Compton telescope for imaging cosmic sources in the 0.15 to 10 MeV energy band.

[6][7][8] Since 2001, Aprile's research focus shifted to particle astrophysics, specifically to direct detection of dark matter with liquid xenon.