She also appeared as Verdi's Azucena at the Metropolitan Opera, the Deutsche Oper Berlin and Opéra Bastille, and as Amneris at the Arena di Verona.

[3] While a student at the conservatory, she performed at the Saratov Opera, and made her debut as Marfa in Mussorgsky's Khovanshchina.

Her roles have included Helene Bezukhova in Prokofiev's War and Peace, Marina in Mussorgsky's Boris Godunov, Princess Evpraksia Romanovna in Tchaikovsky's The Enchantress, Epanchina in Weinberg's The Idiot, and Ježibaba in Dvořák's Rusalka.

[10][11] In 2022, when a castmember became ill, Manistina was flown in from Moscow to sing the part of Princess for the first performance of Tchaikovsky's The Enchantress at the Oper Frankfurt.

[12][13] While the assistant director played the part onstage, Manistina sang from the side with a powerful voice and "explosive singing".