During the early twentieth century, she performed at major opera houses in the United States, Cuba, Europe, Australia, New Zealand, South America and Russia.

Cisneros toured the United States during World War I, singing in plays at no charge to raise funds for the Red Cross and marketing millions of dollars worth of Liberty bonds.

[9] After performing in New York City she then went to Philadelphia in a hurry and filled in as a contralto, with no rehearsal, in Il trovatore by Giuseppe Verdi at the Metropolitan Opera.

[5] At this theatre in this year she established the part of Candia della Leonessa in La figlia di Iorio by Alberto Franchetti.

[12] She sang also the same year in the theatre the first performances of The Queen of Spades by Pyotr Ilyich Tchaikovsky and Salome by Richard Strauss.

[12] After her initial European tour Oscar Hammerstein had her come back to New York City to perform at the Manhattan Opera House, where she sang for two seasons from 1906 to 1908 as a leading singer.

[12][13] Cisneros performed in dozens of opera roles in the Italian cities of Trieste, Ferrara, La Spezia, Milan, Modena, and Turin.

[14] Cisneros sang in her mezzo-soprano opera voice the roles of Brünnhilde, Ortrud, Venus, Delilah, and Amneris.

[12] Australian opera singer Nellie Melba declared that Cisneros performed the greatest Delilah in the world.

[6][12] She stood at 6 feet 2 inches and presented a queenly majestic appearance, which was ideal for her performances representing heroes.

[12] With her mezzo-soprano opera voice she sang difficult roles like that of Santuzza, Gioconda, Kundry, Carmen, Laura, Urbain, and Azucena.

[15] One such song is Thomas Dunn English's poem Ben Bolt, recorded on an Edison Blue Amberol cylinder in 1912.