Mekhaled made her professional debut on 12 November 2016, scoring a four-round points decision (PTS) victory against Jacinthe Berenguer at the Palais des Sports René-Bougnol in Montpellier, France.
[2] She began 2017 with two PTS victories—Valentina Keri in January[3] and Bilitis Gaucher in February[4]—before defeating Wendy Vincent via fourth-round technical knockout (TKO) for the vacant French female super-featherweight title on 17 March at the Salle La Cotonne in Saint-Étienne, France.
[5] After six more wins, including two defences of her French title, Mekhaled defeated Marina Sakharov via ninth-round TKO, capturing the vacant European female super-featherweight title on 22 December 2018 at the Palais des Sports Jean Capievic in her home town of Vaulx-en-Velin.
[6] In her next fight she faced Danila Ramos for the vacant WBC interim female super-featherweight title on 16 March 2019 at the W Hotel in Barcelona, Spain.
Mekhaled captured her first world title, albeit an interim version, via ten-round unanimous decision (UD).