[3] Blake soon abandoned the study of law at the request of his uncle, Eli Whitney, who desired his assistance in erecting and organizing the gun factory at Whitneyville.

On December 31, 1833, he, with brothers Philo and John, patented an "Escutcheon Latch", the first mortise lock produced in the United States.

[4] In 1836, under the firm name of Blake Brothers, they established at Westville a factory for the production of door locks and latches of their own invention.

This problem he solved in 1857, by the invention of the Blake stone breaker, which, for originality, simplicity, and effectiveness, was justly regarded by experts as unique.

He contributed valuable papers to the American Journal of Science and other periodicals, the most important of which he published in a single volume as Original Solutions of Several Problems in Aërodynamics (1882).