[8] In both 2023 and 2024, Spizzirri was named to the College Sports Communicators (CSC) Academic All-American Men's Tennis Team, earning first-team honors both years and in 2024, he was named the Team Member of the Year, the organization's top honor for men's tennis.

[10] In October 2023, Spizzirri captured the singles title at the ITA Men's All-American Championships, becoming the third player from Texas to do so.

[15] In 2021, Spizzirri won the singles ITF Futures title in Decatur, Illinois and captured the doubles ITF Futures title in Champaign, Illinois, with Ben Shelton[16] Spizzirri received a wildcard into the singles qualifying round of the 2021 US Open, where he defeated world No.

He also received a wildcard into the doubles main draw that year with Tyler Zink, where they lost in the first round.

Spizzirri competed in the ATP 2023 Lexington Challenger, winning the doubles championship with Tyler Zink with a defeat over George Goldhoff and Vasil Kirkov, and also reached the second round in singles.

That year he also received a wildcard into the doubles main draw again with Tyler Zink, where they lost to French duo Adrian Mannarino (No.

Spizzirri has won two ITF World Tennis titles in 2024, capturing the M25 Tulsa, USA in June[17] and the M25 Laval, Canada in July.

[19] He recorded his first main draw ATP Tour win at the 2024 Hall of Fame Open over Li Tu as a wildcard.