[1][2] She spent her childhood in Salluit, Nunavik, Quebec, and moved to Montreal in 1999 to pursue communication studies in order to become a journalist.

[5] Isaac collaborated with instrumentalist Alain Auger in the musical project Taima (Inuktitut for "that's all" or "it is done"[6][7]) in the early 2000s.

The band's sole album, Taima, won the Juno Award for Aboriginal Recording of the Year in 2005.

In 2006, Isaac wrote lyrics for songs composed by Bruno Coulais for the film The White Planet.

Roy's forthcoming augmented reality film, V F C.[12] She also had a part in the television crime drama series Motel Paradis in 2022.

In 2023, she released the album Inuktitut, consisting of ten Inuktitut-language covers of classic pop and rock songs.