Although Samuel was not as outspoken as his wife, he shared her beliefs and together, they opened their home in Valley Falls, Rhode Island as a Station on the Underground Railroad, at great personal risk, to runaway slaves helping them escape to Canada.

In 1835, Elizabeth helped to found the Fall River Female Anti Slavery Society, after the original group struggled to integrate the free black women who wished to join as members.

The bust of Elizabeth Buffum Chase was created and sculpted by the Bolivian born artist Pablo Eduardo of Gloucester, Massachusetts.

Their daughter, Lillie Buffum Chace Wyman, became an author publishing several books and writing regularly for such magazines as The Atlantic Monthly in addition to being a tireless social reformer.

Samuel and Elizabeth's grandson, Malcolm Greene Chace, was a US Collegiate Tennis Champion, and father of American ice hockey.

Richard played a crucial role as Scientific Liaison for the United States Army on the Manhattan Project, and Edward, a pioneer in Behaviorism, successfully sued the University of California, Berkeley for firing him for refusing to sign the infamous Loyalty Oath of the 1950s during the McCarthy Era.