[1][2] Defau Fulton had left Virginia to become a Methodist missionary to the Cherokee in North Georgia.

[3] In 1856, she moved to Tishomingo, Chickasaw Nation, Indian Territory to work at a missionary school.

[4][2] In 1861, she moved with her husband, George Hester, to Boggy Depot, Choctaw Nation, Indian Territory.

In 1878, she returned to Tishomingo helped form Indian Territory Woman's Foreign Missionary Society of the Methodist Episcopal Church, South.

[3] Hester worked as a nurse for the Confederate Army during the American Civil War in Boggy Depot, while her husband George was a captain.