In 2023, she ran to represent Virginia's 29th Senate district, failing to unseat incumbent Jeremy McPike by only 50 votes.

As a Delegate, Guzmán passed legislation to repeal Virginia's Jim Crow-era prohibition on public sector collective bargaining and provide paid sick leave to home health care workers.

[4][non-primary source needed] Born in Peru, Guzmán immigrated to the United States and became a social worker.

Guzmán was invited by Nancy Pelosi to deliver the Spanish language response to the 2018 State of the Union Address,[8][6] As a Delegate, Guzmán passed legislation to repeal Virginia's Jim Crow-era prohibition on public sector collective bargaining and provide paid sick leave to home health care workers.

[15] In December 2022, Guzmán announced her intention to challenge incumbent senator Jeremy McPike in the Democratic primary.