[11] During her time in New York, Laime got involved with the Upright Citizens Brigade Theatre and joined the sketch Maude team Gunderson!
[13] Her short story of a failed athletic endeavor, "Swim Team 1996", was published in the book Rejected.
She hosted the show with her husband Andy Rosen and would chat with a guest, usually an actor or improviser from the Los Angeles comedy scene.
Whitney Matheson, writing in USA Today, listed Totally Laime in her personal top ten comedy podcasts.
In explaining her decision to end the show, Laime stated that "it feels like the right time (to end the show)" and cited other reasons such as the responsibility of taking care of her child, working on her writing job and difficulty in booking guests.
The tone and format of the show is largely unchanged with only the Oprah Game being replaced by Questions From a Cup.
The show covered parenting stories from the hosts' personal lives and answered questions submitted by listeners.
In 2015, Laime wrote and developed a comedy project Crystal with ABC Studios under a production deal with Casey Wilson and June Diane Raphael.
[22][23] The show would center on "Crystal, a hustler from the wrong side of the trailer park who, fresh out of prison, lands a job in the suburbs as an in-home health aide.
In 2018 the script for Totally Laime was performed before a live audience and released as part of the Dead Pilot's Society podcast.
[27] The cast of the live table read included Jason Ritter, Jamie Denbo, and Lucas Neff.
[33] In 2018, Laime came forward along with 15 other women in a CNN article accusing New York City voice acting coach Peter Rofé of sexual assault and misconduct.