[4] In her first three years, based in New York City, she managed relationships of JPMorgan with financial institution in Belgium, Holland, and Luxembourg.

[6] She helped the founding board create the Gambia Women's Finance Association as well as start-up microfinance institutions in Mali, Senegal, Mauritania, Rwanda, and Burundi.

In April 1990, Littlefield moved to London to establish the Emerging Market Sales and Trading business for JPMorgan, in which capacity she was Head Debt Trader for Africa, Eastern Europe, and Asia.

[8] In 1999, she was recruited to serve in a joint capacity as a Director of the World Bank's Financial and Private Sector Division, and chief executive officer of The Consultative Group to Assist the Poor from 1999 to 2010 a microfinance think tank.

[9] From 2007 to 2008, Littlefield was an adjunct professor leading a graduate course on Financial Sector Reform and Global Development at SAIS, the Paul H. Nitze School of Advanced International Studies of the Johns Hopkins University.

[14] From 2010 to 2017, Littlefield served as the chairman, President and CEO of the Overseas Private Investment Corporation (OPIC), the U.S. Government's development finance agency during the Obama administration.

[15] In this role, an Under Secretary-level position,[16] she managed OPIC's $29 billion portfolio of financing and insurance to support private investment in developing countries.