Comstock was a very active spokesperson who educated people about those stricken by illness in places such as hospitals and prison camps.

In the time of the American Civil War, Comstock worked to relieve people who had recently been freed.

After the civil war and the slaves were freed she assisted with their transition to citizenship running the Kansas Freedmen's Relief Association.

[9] After the war, Comstock continued to advocated for prison reform, temperance, peace, women's rights, home-mission welfare work and how to adapt to urbanization.

[4][10] In 1879, Comstock toured the country raising funds, for the "Exodusters," the numerous black emigrants from the South to Kansas.