[10] Muth also had a guest role in "Don't Ask", the original unaired pilot episode of the 2000 Fox show that eventually aired as Normal, Ohio.

[11] That year, Muth played the lead in the Lifetime Original Movie The Truth About Jane about a high school girl's struggle with her sexuality and acceptance.

Muth starred in the 2003–04 Showtime television series Dead Like Me in the role of Georgia "George" Lass, the protagonist and one of a team of grim reapers.

[14] In September 2008 she joined three other actors at the Theatre Artist Workshop in Norwalk, Connecticut, in a reading of Fleece the Flock, an original musical comedy in development and directed by Joel Vig.

[17] In 2013, Muth made a guest appearance in two episodes of the first season of the TV series Hannibal, produced by Bryan Fuller, the creator of Dead Like Me.