There it passes by the toxic Pfohl Brothers Landfill and the Buffalo Niagara International Airport.

At Williamsville's Island Park Ellicott Creek splits briefly into two channels, one of which contains floodgates.

After Glen Falls, Ellicott Creek continues flowing generally north and northwest through Amherst.

It passes by several golf courses and then through the northern edge of the campus of the University at Buffalo, after which the creek turns to the west and crosses under Interstate 990 (Lockport Expressway).

In 1990, the Ellicott Creek Bike Path was the last known location where Linda Yalem—a UB sophomore running on the path—was alive before being raped and killed by Altemio Sanchez.