Born in Bristol[2] Genge grew up on the Knowle West council estate,[4] and was educated at John Cabot Academy.

[7] At sixteen, Genge moved to Hartpury College and captained their rugby team to victory in the AASE league.

[8] According to Genge, he was first introduced to the front row by former England youth coach Bobby Walsh originally to have as an additional option but this eventually resulted in a permanent career change.

[7] He went on loan to Clifton to play loosehead prop in National 2 South during the 2014–2015 season starting thirteen games and coming on as a substitute in one other match.

Genge made his professional debut for Bristol on 8 December 2013 in the British and Irish Cup against Scottish side Gala, scoring a try in a 62–7 win.

[11][12] Later that year he started for the side that lost to New Zealand in the final of the 2015 World Rugby Under 20 Championship to finish runners up.

[10][16] He made his Leicester debut as substitute against Wasps on 12 March 2016, replacing Marcos Ayerza, and his first start came on 7 May 2016 against Bath at the Rec.

[28] Genge revealed that closeness to family and the ability to see them regularly played a key part in his decision, with covid lockdowns having caused him to re-assess his priorities.

[33] Genge scored his first international try in a warm-up game for the 2019 Rugby World Cup against Italy at St James' Park.

[37] After the delay caused by the COVID Pandemic lockdown he came off the bench in the final round of the competition as England beat Italy to win the tournament.

[41] He was prominent during the second test victory in Brisbane and then started again in the decisive final match as England defeated Australia at Sydney Cricket Ground to win the series.