Gabel's global breakout role was portraying computer genius Walter O'Brien in the CBS series Scorpion (2014–2018).

[21] Gabel made his debut in 2001 as the character Jean-Claude Tournier in episode titled Breaking point of series 15 of BBC medical drama Casualty.

He went on to appear as Danny in Charlie Brooker's horror comedy drama miniseries based on a zombie outbreak titled Dead Set.

In the same year, he played Shahrouz in the second series of Psychoville and as Ahmed in war torn Baghdad based hostage drama Kingdom of Dust (2011).

[30] In 2011, he joined the cast of CIA procedural Fox pilot Exit Strategy, portraying transport expert Tarik Fayad alongside Ethan Hawke[31] but the show was dropped after being considered for a midseason airing[32] and later released as a television film.

That same year, Gabel founded his own production company Roughened Verse Entertainment and went to pursue more roles in the United States.

In 2013, Gabel starred as Detective Adam Lucas in the third season of the American medical/crime comedy drama television series, Body of Proof on ABC.

[39] He appeared as Ruan Sternwood in Eran Creevy's action thriller Welcome to the Punch alongside James McAvoy, Mark Strong, and Andrea Riseborough.

[46][47] Scorpion also won The Golden Nymph award for 'Best Action & Science Fiction TV Series' in Monte-Carlo Television Festival (2018).

[52] In the same year, he made an appearance in a crossover episode of Scorpion with American action television series NCIS: Los Angeles.

[53] In Christopher Nolan's science fiction film Interstellar,[54][55] which premiered on 26 October 2014, Gabel had a small cameo appearance as the administrator who fanboyed over the lead character played by Matthew McConaughey and showed him to his quarters.

"[58] In 2015, he appeared as Adem Qasim, again a Supporting Lead role, in British spy thriller film Spooks: The Greater Good alongside Kit Harington and Jennifer Ehle.

[67][68] In 2017, Gabel directed the pilot episode titled "Black White & a shade of grey" of TV series Stakes.

[70] As the third filmmaker project of 2017, Gabel directed and produced a short feature film titled Grimshaw[71] based on drug addiction and regression of individual freedom.

[80][81] In 2008, Gabel recorded a single along with Luke Bailey, Stephen Nicholas, Lee Otway, Junior Witter and Girls Aloud, under the collaboration UK Flow, a campaign aimed at raising money to fight the spate of knife crimes.

[80][81] In 2008, he joined actors and sports stars to record a rap-single to support the Anti-knife campaign and raising money to fight the spate of knife crimes.