Emanuele Di Gregorio (born 13 December 1980 in Castellammare del Golfo, Sicily) is a track and field sprint athlete who competes internationally for Italy.

[1] He achieved a new personal best at the 2009 European Athletics Indoor Championships in Turin with a 6.56-second run for the 60 metres dash.

He succeeded at the regional level with a silver medal in the 100 m at the 2009 Mediterranean Games, before adding the relay gold to his honours.

He ran at the 2009 World Championships in Athletics, reaching the 100 m quarter-finals and he also helped the men's 4×100 metres relay team to sixth in the final.

He ran a personal best in the 100 m at the 2010 European Athletics Championships, finishing in 10.17 seconds into a headwind to earn himself a place in the event final.