The embassy also covers the countries of Sudan, Libya, and South Africa as part of its mandate.

The first ambassador of Armenia to Egypt was Dr. Eduard Nalbandyan (1992–1999) who was followed by Dr. Sergey Manassarian (1999–2004) and then by Dr. Rouben Karapetian (2004–2009).

From July 22, 2009 to November 2018 Dr. Armen Melkonian[1] was Armenia's 4th ambassador to Egypt.

Since November 20, 2018 Mr Karen Grigorian is Ambassador Extraordinary and Plenipotentiary of Armenia to Egypt.

The villa designed by local architect A. Antranikian in 1927 and originally belonged to Janik and Satenig Chaker and was donated by the latter to the Cairo branch of AGBU in 1976.