To this day, Emecé precedes its works with an epigram from Miguel de Cervantes, to whom the series is dedicated: that books "are honest entertainment, delight with their language, and amaze and suspend [disbelief] with their invention."
Where possible, Emecé has attempted to include major works of artistic and cultural interest, ranging from Toynbee, Malraux, Matisse, Kandinsky, Francastel, and Huyghe to deluxe editions of Don Quixote.
The house is known for its detailed coverage of Argentine topics, including Martín Fierro, the works of Bonifacio del Carril (in particular his Monumenta Iconográfica), records of Argentina's Pre-Columbian inhabitants (such as the Inca and Diaguita), and the history of the gaucho.
It has since widened its scope to include writers of popular fiction, such as Arthur Hailey, Erich Segal, Frederick Forsyth, Colleen McCullough, Stephen King, John le Carré, Leon Uris, Tom Clancy, Ken Follett, Arthur C. Clarke, Judith Krantz, Mary Higgins Clark, Scott Turow, Dean Koontz, Michael Crichton, Wilbur Smith, and Sidney Sheldon.
They, along with Bioy Casares, Ernesto Sabato, Eduardo Gudiño Kieffer, Isidoro Blaisten, Abelardo Castillo, Abel Posse, César Aira, and Margarita Aguirre, number among more than three hundred Argentine writers in the Emecé catalogue.