[4] Following the rampant hyperinflation in 1989, Insolera's family moved back to Italy, first to Sicily later to various cities frequently, eventually setting in Rome.

Prior to completing high school, Insolera was awarded the Fulbright and Roberto Wirth scholarship to attend Gallaudet University, in Washington, D.C., the only liberal arts college for the Deaf in the world.

After freelancing for various indie film houses and working for MTV in New York City, he pursued and obtained a master's degree in Mass Communication with summa cum laude honors from the University of Rome La Sapienza.

On Los Angeles Times, Michael Rechtshaffen describes the "fresh, unique filmmaking voice" as a "fast-paced potpourri of stock footage combined with sign-language and stroboscopic action sequences performed by a deaf cast, video effects simulating grainy, scratchy film stock and that aforementioned all-enveloping sound mix, with an end result that proves as wildly inventive as it is empowering".

[16] On Corriere della Sera, Michela Trigari calls Sign Gene a film that uses the science fiction as a medium to capture the imagination and "make visible what is invisible to the eyes".

[15] The film is making waves, and has inspired Elena Pizzuto, an Italian linguist, to declare it "the symbol of activism for the visual community"[21] and Paul Dakin, from Hektoen International, an "unlikely cult classic".

[25][26] Starting from January 2019, Insolera collaborates with Striscia la notizia, an Italian satirical television program on the Mediaset controlled Canale 5 on the production of various shows.

[32] In September 2019, it was announced that Insolera had joined the Simon Kinberg espionage The 355 alongside Jessica Chastain, Penélope Cruz, Diane Kruger, Lupita Nyongo, Bingbing Fan, Edgar Ramirez and Sebastian Stan.

[33] Academy Award Winner for Best Actress Jessica Chastain helped Insolera get an audition with Simon Kinberg and he landed the role of Giovanni Lupo, a hacker.

Together with researchers Elena Radutzky and Mauro Mottinelli, he produced the first Italian Sign Language dictionary in digital format, which is now available on DVD and as an app.