At the 2021 Miami Open, Nava qualified for the main draw to make his debut at ATP Masters 1000 level but lost in the first round to Lloyd Harris.

[6] Nava made his Grand Slam debut at the 2021 US Open after being given a wildcard for the singles main draw.

182, he received a wildcard for the main draw of the 2023 Miami Open for a consecutive year, recording his first Masters 1000 win over John Isner in straight sets with two tiebreaks.

He made his main draw debut at the 2023 French Open as a qualifier, losing to Roberto Carballés Baena.

[12] He also qualified for the 2024 Los Cabos Open defeating wildcard Nicolás Mejía and again alternate player Aidan Mayo.

[14] At the next Masters, the 2024 Miami Open, he reached the main draw after qualifying with wins over Quentin Halys and Yoshihito Nishioka.