She co-wrote the 2017 romantic comedy film The Big Sick, based on her relationship with her husband and frequent collaborator, comic Kumail Nanjiani.

[4] In 2011, she was asked by Chris Hardwick, who wanted to turn the space into a curated comedy venue, to act as program director.

[citation needed] In 2013, Comedy Central ordered a pilot for The Meltdown with Jonah and Kumail, which was made a series in 2014;[4] Gordon was an executive producer.

[9][10] Gordon also co-wrote the screenplay of and co-executive produced the 2017 film The Big Sick, with her husband Kumail Nanjiani.

[16] She met Nanjiani at a comedy show in Chicago where he was performing and she lightly heckled him, an encounter depicted in The Big Sick.

[16] In the ensuing months, they began dating but Gordon fell seriously ill and was put into a medically induced coma before being diagnosed with Still's disease.