In 2002, Hughes helped as a co-founder of the feminist genderqueer artist collective and annual literary journal Lesbians To The Rescue (LTTR), which remained an active part of the queer art theory community until 2008, along with Ginger Brooks Takahashi and K8 Hardy.
"[6] In addition to their essay being published in Grand Arts and Toronto's C Magazine, the project also was inclusive of a "practice, partial philosophy, set of strategies, and group exhibition(s)" that were all organized and curated by Hughes.
Steiner, Joyce Wieland, Leah Gilliam, Julianna Snapper, PIG/ Politically Involved Girls (Wu Ingrid Tsang, Zackary Drucker, and Mariana Marroquin), and Ian White.
[7] The New York Times' Roberta Smith wrote that "Ms. Roysdon's title connotes a spirit of Zen activism, with absurdity substituting for ideology, but with politics still in the picture.
"[8] Hughes's many other collaborations include costume design for choreographers Levi Gonzalez, Vanessa Anspaugh and Faye Driscoll, as well as lyric writing for The Knife, and JD Samson & MEN.
Recent solo projects include Help the Dead (2019), scenic, say (Kunsthalle Lissabon, Lisbon, 2017), Comedy of Margin Theatre (Secession, Vienna, 2015), and Uncounted (2014-17).