The 18-room mansion, designed by American architect Frank Furness, was built in 1879 for Dr. Emlen Physick Jr. (1855–1916), descendant of a well-known Philadelphia family, his widowed mother, Mrs. Ralston, and maiden Aunt Emilie.
Its exterior is distinguished by Furness's trademark oversized features, including gigantic upside-down corbelled chimneys, hooded "jerkin-head" dormers, and the huge stick-like brackets on the porch.
MAC has restored, maintains and operates the estate as a Victorian historic house museum and offers guided tours year-round.
The Physick Estate was used as a location in the 1981 slasher film The Prowler, which was special effects wizard Tom Savini's second movie.
The mansion was also featured on the season 1, episode 6 of Haunted Towns on Destination America and was investigated by series paranormal team, Tennessee Wraith Chasers (TWC).