In her second season with the Blue Cats, she helped win the team its first national title and was named Belgium Championship MVP.

Meesseman and UMMC Ekaterinburg won the 2015–16 EuroLeague, Europe's premium basketball competition for women, in April 2016.

[23] In 2017, after the Mystics traded Dolson to the Chicago Sky, Meesseman continued her role at the power forward spot in the starting lineup.

[24] During the 2017 season, Meesseman left the Mystics after the first four games due to overseas commitment to play for her national team during the FIBA world championship qualifying tournament.

In the first round elimination game, the Mystics defeated the Dallas Wings 86–76, Meesseman scored 16 points and grabbed 10 rebounds.

[citation needed] In January 2018, it was announced that Meesseman would sit out the entire 2018 season to play for Team Belgium in the 2018 FIBA Women's Basketball World Cup tournament.

With her return and strong contribution off the bench, the Mystics would finish as the number 1 seed with a 26–8 record, receiving a double-bye to the semi-finals.

In the semi-finals, the Mystics defeated the Las Vegas Aces 3–1, advancing to the WNBA Finals for the second year in a row.

Meesseman's presence and off-the-bench heroics earned her Finals MVP honors as the Mystics defeated the Connecticut Sun in five games.

[citation needed] In 2020, the season was delayed and shortened to 22 games in a bubble at IMG Academy due to the COVID-19 pandemic.

[31] During the season, the Mystics were shorthanded with key players leaving in free agency and sitting out for health concerns as they finished 9–13 with the number 8 seed.

[citation needed] Ahead of the 2022 season, Meesseman signed with the Chicago Sky, where she was reunited with her Belgian national teammates Julie Allemand and Ann Wauters (with the latter serving as an assistant coach).

[citation needed] Meesseman led Belgium to a best ever finish in EuroBasket Women 2017, a bronze medal, and was named to the All-Star Five of the tournament.

[41] At the 2020 Summer Games, she led the Belgium women's national basketball team to the quarter-finals, having defeated Australia and Puerto Rico and lost to China in the pool phase.

[43] In February 2024, Belgium hosted one of the three Olympic Qualifying Tournaments in Antwerp and secured on home soil a Paris 2024 quota spot.

[45][46] In the Paris Olympics, the Belgian national team advanced to the semifinals for the first time ever after defeating Spain 79-66 in the quarterfinals.

[47] In the semifinal overtime loss, 75-81, against France, Meesseman was the game's top scorer with 19 points, including a game-tying three-pointer 8 seconds before the end of regulation.