O'Driscoll was drafted by Fremantle with their fourth selection, 51st overall, in the 2019 AFL Women's draft after playing for Swan Districts in the West Australian Women's Football League (WAWFL).

She was named at centre half-back of the AFLW All-Australian team at the season's end,[4] and finished runner-up in Fremantle's Best and Fairest award.

[5] O'Driscoll was elevated to Fremantle's leadership group ahead of the 2024 AFL Women's season.

[6] She was named at centre half-back of the 2024 AFL Women's All-Australian team at the season's end.

Both her brothers are Australian rules footballers; her younger brother Nathan was also drafted by Fremantle with the 27th selection in the 2020 AFL draft,[8] and her youngest brother, Aiden, was drafted to the Western Bulldogs for the 2024 AFL season, but medically retired on 14 May 2024 without playing a game after suffering a head injury during the pre-season.