In November 2005, Wu debuted as one of the original members of Blackie's Teenage Club (Chinese: 我愛黑澀會), a variety show seeking talents for the television network, Channel [V].
[6] After thirteen episodes, the series ended on 7 October 2007, and an official soundtrack was released with songs from Lollipop and Hey Girl.
After the completion of M.I.T., Wu and Aaron, both widely praised for their on-screen chemistry and closeness, were to co-star in Taiwanese drama Momo Love.
Later that year, Wu was cast in the television version of Painted Skin (TV series),[8] in collaboration with Fiona Sit, Chen Yi Rong, and Li Zhong Han.
In 2012, Wu debuted on the big screen with a three part-film series, The Four, starring Ronald Cheng, Anthony Wong, Deng Chao, and Liu Yifei.
"[9] In the consecutive years, Wu has starred in Chinese TV dramas: Legend of Lu Zhen, Incisive Great Teacher (犀利仁師), A Different Kind of Pretty Man (不一樣的美男子), Roommate Diaries (一男三女合租記), The Four (2015 TV series), The Girl Wearing Tassel Earrings (戴流蘇耳環的少女) and The Legend of the Flying Daggers (飛刀又見飛刀 (2016年電視劇)).
On 26 September, Wu released her first official music video, Sugar Rush, and on 7 October, she launched her first self-titled EP, GEMMA.