The Ardlie Street (McAuley) Campus is home to Year 7, 8 and 10 students and is on approximately 20 acres (81,000 m2) of land that incorporates Emmanuel's Agricultural Skills Centre and the Gothic Revival St Ann's Chapel (1888).

[1] There is a senior (Rice) campus nearby, in Canterbury Road which caters for Year 11 and 12 VCE, VET and VCAL Students.

The Sisters of Mercy had purchased the property "Wyton House" and established their convent and "A Day and Boarding School for Young Ladies" by July 1872 on the present site of the Ardlie Street Campus.

By 1987 "the long tradition of combined primary and secondary education" had drawn to a close and the college provided its boys with a years 7–12 curriculum.

These include: music activities (now removed) and performances, public speaking and debating, mooting, Duke of Edinburgh's Award, Science Talent Search and other academic competitions, Eisteddfods, drama productions, a variety of team sports, rowing, equestrian team, agricultural shows, Emmanuel's Interactive Animal Nursery at the Fun4Kids Festival and Field Days, chess, Book Club, optional camps and trips including study tours to France, Japan, New Caledonia, Switzerland and the Rock To Reef tours.

Emmanuel College has created to the development of a number of students who have represented their state and country at world championships and the Commonwealth, Olympic and Paralympic Games.