Nzekwesi scored 22 points without missing a shot against Paul Laurence Dunbar High School during his sophomore season.

[2] He gained the attention of Damian Lillard's trainer, Phil Beckner, and later, Weber State head coach Randy Rahe.

Nzekwesi signed a letter of intent with Weber State, but problems with his visa precluded him from attending the school.

He played a postgraduate season at Moravian Prep in Hudson, North Carolina to help attract more scholarship offers.

Nzekwesi accepted a scholarship offer from Oral Roberts, which had previously recruited him in high school.

[8] On 13 August 2020 Nzekwesi signed his first professional contract with ZZ Leiden of the Dutch Basketball League (DBL).

[9] He made his professional debut on 3 October, recording a double-double with 18 points and 13 rebounds in a 104-102 loss to the Den Helder Suns.

[10] Nzekwesi finished the regular season having led Leiden to the first seed, while leading the league in scoring with 21.7 points and 8.7 rebounds per game.