Emmanuele Vitale (30 April 1758 – 8 October 1802) was a Maltese notary, commander and statesman.

Also between 1785 and 1795, he succeeded his father and held the position of Chancellor of the Università at Mdina, for whom he was a great benefactor.

The French troops left in Malta, under the command of General Claude-Henri Belgrand de Vaubois, immediately became unpopular.

[2] Meanwhile, Vitale and the other leaders set up a provisional government, the National Assembly, at the Banca Giuratale of Mdina on 3 September.

On 31 March 1800, he, along with about twenty other representatives, signed a letter stating that the Maltese wanted to become subjects of Great Britain.

On 21 August 1801, under the Civil Commissioner Charles Cameron, he was given the honour of being Governor, Superintendent and the Health Director of Gozo.