[3] She was educated at a Catholic convent school, and began modelling at the age of fourteen.

[4] Her husband directed her in Frantic (1988), Bitter Moon (1992), The Ninth Gate (1999), Venus in Fur (2013), Based On A True Story (2017) and An Officer and a Spy (2019).

In 2010, Seigner was featured in Jerzy Skolimowski's Essential Killing, which went on to win the Special Jury Prize at the Venice Film Festival.

[5] Seigner appears as the main character in the music video "Hands Around My Throat" by Death in Vegas.

As a member of the band L'Épée, in 2019 she released an album "Diabolique" with The Limiñanas and Anton Newcombe of The Brian Jonestown Massacre.