The hospital was housed in a downtown Atlanta mansion that had been spared from destruction by General Sherman's army during the Civil War.

By November 1922, the hospital had grown too large for its quarters and moved to its current DeKalb County site on the Emory University campus.

News and World Report's "America's Best Hospitals" for several years as one of the nation's top 10 cardiology centers.The latest data show it has 23,710 admissions and performs 9,446 inpatient and 2,843 outpatient surgeries.

[7] On July 31, 2014, the United States government and the Centers for Disease Control announced that Emory Hospital would treat at least one of the patients of the 2014 West Africa Ebola outbreak in a specialized isolation facility.

Brantly and Writebol were the first patients ever to be treated with the experimental drug ZMapp, splitting a dose between both patients; Samaritan's Purse later reported Brantly's condition began to improve within hours of receiving the treatment, although they point out that it is unclear if either the treatment or a blood transfusion, received in Africa from a young Ebola survivor, was responsible for the improvement.

[11][12] On October 15, the U.S. Department of Health and Human Services announced that Amber Vinson, the second case of Ebola transmission in the U.S., would be transferred to Emory.