She was an aunt of Wang Fahui, another empress of the Eastern Jin.
Wang Muzhi's father Wang Meng (王濛) was at one time the chief assistant to a prime minister, but it is not clear which prime minister he served.
She became Emperor Ai's wife while he was still the Prince of Langye during the reign of his cousin Emperor Mu, and she carried the title of Princess of Langye.
[2] She did not bear any children, and died in February 365.
Emperor Mu would die in the following month, from complications of poisoning he suffered by taking pills given him by magicians in search of immortality.