The Ems-Leine-Express (RE 60) is the name of a German Regional-Express service in North Rhine-Westphalia that has connected the Emsland city of Rheine, Lower Saxony, the regional centre of Osnabrück, the east Westphalian city of Minden and the Lower Saxony regional centres of Hanover and Braunschweig since 5 November 2000.

[2] The Ems-Leine-Express is notable for crossing the state border between Lower Saxony and North Rhine-Westphalia (NRW) three times at the following locations: In 1998, the service began in Bad Bentheim and went via Osnabrück to Hanover.

The service was named the Ems-Leine-Express with the introduction of the integrated regular-interval timetable in the whole of North Rhine-Westphalia (NRW-Takt) in 1998.

From west to east the Ems-Leine-Express uses the following lines: Overall, the service between Rheine and Brunswick covers a distance of 270.4 kilometres.

The scheduled time (including intermediate stops) between Rheine and Braunschweig is 3:03, resulting in an average cruising speed of about 90 km/h.