This impairs necessary blood flow and cuts off circulating oxygen, which can lead to tissue death and permanent damage to the brain, heart, arteries, and kidneys.
[3] Recent studies have shown that activation of the immune system may also be closely involved with the development of end organ damage in hypertensive states.
In cases of extremely low circulating volume or inability to maintain an adequate blood pressure, body tissues do not receive enough oxygen and nutrients.
[8] Chronically high insulin levels are also associated with early development of atherosclerotic plaques inside blood vessel walls.
[12] Source:[13] When there is concern for the presence or development of end organ damage, blood pressure should be lowered emergently with intravenous antihypertensive medications.
Patients should be admitted to the hospital to be closely monitored for complications of end organ damage, notably strokes.
[2] Additionally, future treatments may focus not only on blood pressure control but also the reduction of local inflammation that can lead to end organ damage.
Urine output, breathing, and reflexes should be monitored closely with concern for the development of worsening kidney function and magnesium toxicity.
Treatment of the source of infection should resolve low blood pressures that compromise vital organ function.