The significance of endosalpingiosis is not settled; medical experts differ on whether the condition itself causes issues or whether it is an asymptomatic finding.

[2][3] Experts are unclear as the condition itself is a rare finding and lack of knowledge presents itself as a challenge.

Like the uterine endometrium of Endometriosis, estrogen can cause salpingoitic tissues outside of the fallopian tubes to grow and potentially aggravate the surrounding areas.

Similar to endometriosis, cases of endosalpingiosis that cause significant amounts of pain can be treated with excision surgery by a specialist, though this is not a cure.

This prevents the body from reaching high levels of estrogen found in ovulation and further aggravating the condition.